Skip to content. | Skip to navigation

You are here: Home Policies/Compliance Compliance Support IRB Administration UC Collaborative Research

UC Collaborative Research


UC Davis is transitioning to a new online UC IRB Reliance Registry hosted by the UC Office of the President.  This new system applies for all studies covered by the Memorandum of Understanding (MOU) between the UC Campuses.  The MOU allows a UC collaborative research study to be reviewed by a single UC IRB, rather than requiring IRB review at two or more UC campuses where the research will take place.  All new requests must be submitted via the online Reliance Registry, prior to protocol submission to the Reviewing IRB.  Paper versions of the  Notice of Intent to Rely  will no longer be accepted. 

Below is a summary of the process for Reviewing and Relying investigators:

       Reviewing Campus PI  

       Relying Campus PI  

Process Diagram


All first-time users must register with the UC IRB Reliance Registry before they create a new reliance request.  

If you are the Reviewing PI, go to  For first-time registration, click “Register” and complete the “User Registration” form. A temporary password will be sent to your email address. Use the temporary password to log in to the Registry and create a new password. Registration is now complete.

Creating a New Reliance Request

If you are the Reviewing PI, click the Create Request tab. Complete the information regarding your role in the study and the other required fields marked by an asterisk. Make sure to save your entries if you need to log out at any time.

Identify your Relying PIs. The Registry will notify the Relying PIs via email to register and confirm their involvement in the study. Email addresses must be entered accurately as there is no bounce-back function in the system.        

Once all Reviewing and Relying PIs have signed up for the study via the Registry, the Reviewing PI will be able to sign a reliance request form, convert it to a PDF and submit it with their protocol application to their campus IRB for review.        

Upon approval of the study, the Reviewing IRB will add the approval/expiration date, approved protocol, approval letter and any applicable consent forms to the study’s Registry record and an automated email notice will be sent to all PIs and the Relying IRB.

The Relying IRB will review the documents and accept or deny the reliance via the Registry. If accepted, the Relying IRB will electronically record the acceptance in the Registry and all PIs and the Reviewing IRB will be notified of this decision via automated email. Paper versions of the Letter of Acknowledgement will no longer be issued. 

Submitting Continuing Review / Renewals

Reviewing PIs should submit Continuing Review applications of their studies to their campus IRB, as usual. Upon IRB approval, the Reviewing IRB will update the study’s expiration date in the Registry. Note:  No Relying PI can continue work on the study if the Reviewing PI does not submit a renewal on time.

Modifications, Adverse Event Reporting 

As a Reviewing PI, you are also responsible for the timely request of all modifications and for timely reporting to your campus IRB of all adverse events or unanticipated events. This is to be done through normal IRB channels at the Reviewing IRB.   Relying PIs are required to promptly inform Reviewing PIs of all such events. 

Managing Your Studies and Your To-Do List

While the Reliance Registry will send you an e-mail to alert you about a new reliance activity you are involved in, you can also use the Dashboard tab in the Registry to monitor your next steps and get a clear picture of the pending actions by others on your studies. 






Issued 6/1/2012