Office of Research Ancillary Reviews - Office of Research

Ancillary Reviews

In some instances, research will involve certain activities that require specialized review. For example, when a study involves radiation, the research must undergo review by the Radiation Use Committee (RUC).   Ancillary reviews must be initiated by the Principal Investigator. The chart below identifies the required pre- and post- department or other ancillary reviews that must occur before the research activity may begin. If your research meets the requirements for one of the ancillary reviews below, you must submit the research to that Committee according to the Committee’s requirements.

Take the Ancillary Review Questionnaire to identify compliance requirements for your project. This tool is to be used as guidance; there may be additional requirements not listed here.


Ancillary Committee

Required Prior to IRB Submission

Required Prior to or Concurrent with IRB Review

Required After IRB Approval

Institutional Biosafety Committee (IBC)    



Institutional Biosafety Committee (IBC) 

recombinant DNA research or stem cell research



Conflict of Interest Committee (COIC)


Cancer Center Scientific Review Committee (CCSRC) X

Radiation Use Committee (RUC)


Stem Cell Research Oversight Committee (SCROC)


Pathology and Laboratory Clinical Research Oversight Committee (CROC)


Information Technology Evaluations for Research (IT)



In This Section 


Institutional Biosafety Committee (IBC)

Required when research involves:

    • Recombinant DNA
    • Materials that are infectious (or potentially infectious) to plants, animals, or humans (including replication-defective viral vectors)
    • Materials that fall under the Cal OSHA Bloodborne Pathogen Standard. This includes any work with human cell lines, human blood or blood products, and human body fluids
    • Storage of biohazardous materials that are not being used

Purpose is to see if research complies with NIH Guidelines and UC Davis requirements

Includes a review by Occupational Health

Outcome of review includes:

    • A recommendation for the level of medical surveillance of personnel associated with the research project
    • Recommendations for modifications, curtailment or termination of any projects when such actions are in the best interest of the health and safety of the community.

Researchers must contact the IBC prior to conducting research:

Phone: (530) 752-1493



Conflict of Interest Committee (COIC)

Researchers are required to disclose actual and potential conflicts of interest the Conflict of Interest Committee as described in HRP-055.

The Conflict of Interest Committee (COIC) at UC Davis is focused on evaluating financial interests related to research projects.  The COIC shares documentation and information with the IRB.  The IRB has the final authority and may add requirements that are not included in the management plan of a COIC determination.

See our Financial Conflicts of Interest page for more information.


Cancer Center Scientific Review Committee (CCRC)

Required when the protocol involves participants with cancer or data about cancer patients

The purpose is to provide a centralized mechanism for prospective evaluation of scientific merit, resource allocation, and clinical cancer research monitoring

Principal Investigators must contact the CCSRC for the review and approval of their research

CCSRC Approval is not required for Single Patient IND trail

The IRB will not review the submission until CCSRC review is completed, when required

Contact Frozan Wahaj:

Phone: (916) 734-2596


Radiation Use Committee (RUC)

Required when research involving humans as participants uses radioactive materials and ionizing radiation (including diagnostic x-rays/fluoroscopy/ DEXA).

Purpose is to ensure the research complies with UC Davis’s Radioactive Material License and state and federal regulations.

The IRB will not review the submission until RUC review has been completed, when review is required.

Principal Investigators must contact the Radiation Use Committee for review and approval of their study prior to IRB review and approval. The RUC may require amendments to the design of the study, restrictions, or specific wording in the informed consent document.

The IRB will withhold approval of a research study involving radiation without the prior approval/exemption of the Radiation Use Committee.

Contact Linda Kroger:

Phone: (916) 734-3355


Stem Cell Research Oversight Committee (SCROC)

ALL UC Davis research activities involving human stem cell research, regardless of the type of stem cells or whether the stem cells are adult or embryonic, must be submitted to SCROC and receive approval from SCROC before commencing any research.

The purpose is to:

    • Determine the scientific merit of the protocol
    • Ensure the research complies with relevant state and federal law and guidance
    • Facilitate education for investigators conducting research involving human adult and embryonic stem cell research

Principal Investigators must contact the Stem Cell Research Oversight Committee to obtain review and approval of their research study after IRB review and approval.

Contact Research, Compliance, Integrity (RCI):

Phone: (530) 752-2454



Pathology and Laboratory Clinical Research Oversight Committee (CROC)

Required when research involves any laboratory testing or clinical laboratory sample retrieval, including tissue specimens through the UC Davis Medical Center (flier).

The purpose is to discuss the services investigators need from the Pathology Department and determine whether and how the services can provided. Contact the Department of Pathology and Laboratory Medicine before designing your study. Certain types of laboratory tests, activities, and tissue examination may require prior approval by the Laboratory Section Medical Director.

Please submit Pathology and Laboratory requests to CROC by completing this form: Pathology Intake Form

Contact UCDMC Pathology:





Information Technology (IT) Evaluations for Research

Required when research includes implementation or use of new applications, systems or devices that collect and/or transmit sensitive identifiable information such as  Protected Health Information (PHI) or Personally Identifiable Information (PII)

Purpose is to determine if the new technology is secure and complies with UC policies as well as state and federal regulations.

Some examples of research-related technologies that have been evaluated include:

  • Mobile devices that are used to gather research data on human subjects
  • Software that would be implemented on the UCDHS network or that would be used to access the UCDHS network
  • Clinical devices that require network access or involve data transfer

Contact IT Evaluation:


Principal Investigators must obtain IT evaluation prior to the start of the study. Contact the IT Department prior to submitting to the IRB to avoid delays in study start-up.


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